Evidence does not currently support medical marijuana for depression or depressive symptoms.²
When depression is present with another condition that is qualifying, such as cancer, a physician may certify a medical marijuana order.
| 1. It is important to discuss the type of medical marijuana being considered with your physician. | 2. Discuss if you are taking any prescription medications for depression. | 3. Discuss if you have other mental health conditions, such as anxiety. |
| THC has been shown to make pre-existing depression worse. Research is not clear on how CBD affects pre-existing depression. |
Certain antidepressants are not safe to combine with medical marijuana, such as tricyclic antidepressants. Other antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), have low to moderate risk when combined with medical marijuana, but should be used with caution. St. John’s Wort is an over-the-counter supplement used for depression, which can decrease effectiveness of CBD. |
Research is not clear on how medical marijuana may affect depressive symptoms when present with another mental health condition. |
Please note: This document is for informational purposes only, but is not medical or legal advice and should not be used to make healthcare decisions. Please consult your healthcare provider to find out what treatment options are available for you.
1 The 2020 Florida Statutes. Title XXIX, Chapter 381, section 381.986: Medical use of marijuana.
2 Black N, Stockings E, Campbell G, et al. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry. 2019;6(12):995-1010
3Stanciu CN, Brunette MF, Teja N, Budney AJ. Evidence for Use of Cannabinoids in Mood Disorders, Anxiety Disorders, and PTSD: A Systematic Review [published online ahead of print, 2021 Feb 3]. Psychiatr Serv.
Updated August 2021
